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ea0063p814 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Abnormal serotonin regulatory loop in adrenals of patients with Cushing’s syndrome and 21-hydroxylase deficiency

Le Mestre Julie , Duparc Celine , Reznik Yves , Bonnet-Serrano Fideline , Touraine Philippe , Chabre Olivier , Young Jacques , Sibony Mathilde , Gobet Francoise , Raverot Gerald , Bertherat Jerome , Louiset Estelle , Lefebvre Herve

In the human adrenal gland, serotonin (5-HT), released by subcapsular mast cells stimulates corticosteroid secretion through activation of type 4 serotonin receptors (5-HT4R) positively coupled to cAMP/proteine kinase A (PKA) signaling pathway and calcium influx. The 5-HT4R is principally expressed in zona glomerulosa cells explaining why 5-HT strongly stimulates aldosterone production but only exerts a modest stimulatory action on cortisol. Interestingly, in primary pigmented...

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Abnormal serotonin regulatory loop in adrenals of patients with Cushing’s syndrome and 21-hydroxylase deficiency

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